Shedding Light on the Blood–Brain Barrier Transport with Two-Photon Microscopy In Vivo

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Shedding Light on the Blood–Brain Barrier Transport with Two-Photon Microscopy In Vivo. / Kucharz, Krzysztof; Kutuzov, Nikolay; Zhukov, Oleg; Janiurek, Mette Mathiesen; Lauritzen, Martin.

In: Pharmaceutical Research, Vol. 39, 2022, p. 1457–1468.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kucharz, K, Kutuzov, N, Zhukov, O, Janiurek, MM & Lauritzen, M 2022, 'Shedding Light on the Blood–Brain Barrier Transport with Two-Photon Microscopy In Vivo', Pharmaceutical Research, vol. 39, pp. 1457–1468. https://doi.org/10.1007/s11095-022-03266-2

APA

Kucharz, K., Kutuzov, N., Zhukov, O., Janiurek, M. M., & Lauritzen, M. (2022). Shedding Light on the Blood–Brain Barrier Transport with Two-Photon Microscopy In Vivo. Pharmaceutical Research, 39, 1457–1468. https://doi.org/10.1007/s11095-022-03266-2

Vancouver

Kucharz K, Kutuzov N, Zhukov O, Janiurek MM, Lauritzen M. Shedding Light on the Blood–Brain Barrier Transport with Two-Photon Microscopy In Vivo. Pharmaceutical Research. 2022;39:1457–1468. https://doi.org/10.1007/s11095-022-03266-2

Author

Kucharz, Krzysztof ; Kutuzov, Nikolay ; Zhukov, Oleg ; Janiurek, Mette Mathiesen ; Lauritzen, Martin. / Shedding Light on the Blood–Brain Barrier Transport with Two-Photon Microscopy In Vivo. In: Pharmaceutical Research. 2022 ; Vol. 39. pp. 1457–1468.

Bibtex

@article{8ac6c32dc72f4dc298512f43c6be6a54,
title = "Shedding Light on the Blood–Brain Barrier Transport with Two-Photon Microscopy In Vivo",
abstract = "Treatment of brain disorders relies on efficient delivery of therapeutics to the brain, which is hindered by the blood–brainbarrier (BBB). The work of Prof. Margareta Hammarlund-Udenaes was instrumental in understanding the principles ofdrug delivery to the brain and developing new tools to study it. Here, we show how some of the concepts developed in herresearch can be translated to in vivo 2-photon microscopy (2PM) studies of the BBB. We primarily focus on the methodsdeveloped in our laboratory to characterize the paracellular diffusion, adsorptive-mediated transcytosis, and receptor-mediatedtranscytosis of drug nanocarriers at the microscale, illustrating how 2PM can deepen our understanding of the mechanismsof drug delivery to the brain.",
keywords = "Faculty of Health and Medical Sciences, Drug delivery",
author = "Krzysztof Kucharz and Nikolay Kutuzov and Oleg Zhukov and Janiurek, {Mette Mathiesen} and Martin Lauritzen",
year = "2022",
doi = "10.1007/s11095-022-03266-2",
language = "English",
volume = "39",
pages = "1457–1468",
journal = "Pharmaceutical Research",
issn = "0724-8741",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Shedding Light on the Blood–Brain Barrier Transport with Two-Photon Microscopy In Vivo

AU - Kucharz, Krzysztof

AU - Kutuzov, Nikolay

AU - Zhukov, Oleg

AU - Janiurek, Mette Mathiesen

AU - Lauritzen, Martin

PY - 2022

Y1 - 2022

N2 - Treatment of brain disorders relies on efficient delivery of therapeutics to the brain, which is hindered by the blood–brainbarrier (BBB). The work of Prof. Margareta Hammarlund-Udenaes was instrumental in understanding the principles ofdrug delivery to the brain and developing new tools to study it. Here, we show how some of the concepts developed in herresearch can be translated to in vivo 2-photon microscopy (2PM) studies of the BBB. We primarily focus on the methodsdeveloped in our laboratory to characterize the paracellular diffusion, adsorptive-mediated transcytosis, and receptor-mediatedtranscytosis of drug nanocarriers at the microscale, illustrating how 2PM can deepen our understanding of the mechanismsof drug delivery to the brain.

AB - Treatment of brain disorders relies on efficient delivery of therapeutics to the brain, which is hindered by the blood–brainbarrier (BBB). The work of Prof. Margareta Hammarlund-Udenaes was instrumental in understanding the principles ofdrug delivery to the brain and developing new tools to study it. Here, we show how some of the concepts developed in herresearch can be translated to in vivo 2-photon microscopy (2PM) studies of the BBB. We primarily focus on the methodsdeveloped in our laboratory to characterize the paracellular diffusion, adsorptive-mediated transcytosis, and receptor-mediatedtranscytosis of drug nanocarriers at the microscale, illustrating how 2PM can deepen our understanding of the mechanismsof drug delivery to the brain.

KW - Faculty of Health and Medical Sciences

KW - Drug delivery

U2 - 10.1007/s11095-022-03266-2

DO - 10.1007/s11095-022-03266-2

M3 - Journal article

C2 - 35578062

VL - 39

SP - 1457

EP - 1468

JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

ER -

ID: 306304419