Testing physical function in children undergoing intense cancer treatment-a RESPECT feasibility study

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Testing physical function in children undergoing intense cancer treatment-a RESPECT feasibility study. / Nielsen, Martin K. F.; Christensen, Jesper F.; Frandsen, Thomas L; Thorsteinsson, Troels; Andersen, Lars B.; Christensen, Karl B; Nersting, Jacob; Faber, Marianne; Schmiegelow, Kjeld; Larsen, Hanne B.

In: Pediatric Blood & Cancer, Vol. 65, No. 8, e27100, 2018.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Nielsen, MKF, Christensen, JF, Frandsen, TL, Thorsteinsson, T, Andersen, LB, Christensen, KB, Nersting, J, Faber, M, Schmiegelow, K & Larsen, HB 2018, 'Testing physical function in children undergoing intense cancer treatment-a RESPECT feasibility study', Pediatric Blood & Cancer, vol. 65, no. 8, e27100. https://doi.org/10.1002/pbc.27100

APA

Nielsen, M. K. F., Christensen, J. F., Frandsen, T. L., Thorsteinsson, T., Andersen, L. B., Christensen, K. B., Nersting, J., Faber, M., Schmiegelow, K., & Larsen, H. B. (2018). Testing physical function in children undergoing intense cancer treatment-a RESPECT feasibility study. Pediatric Blood & Cancer, 65(8), [e27100]. https://doi.org/10.1002/pbc.27100

Vancouver

Nielsen MKF, Christensen JF, Frandsen TL, Thorsteinsson T, Andersen LB, Christensen KB et al. Testing physical function in children undergoing intense cancer treatment-a RESPECT feasibility study. Pediatric Blood & Cancer. 2018;65(8). e27100. https://doi.org/10.1002/pbc.27100

Author

Nielsen, Martin K. F. ; Christensen, Jesper F. ; Frandsen, Thomas L ; Thorsteinsson, Troels ; Andersen, Lars B. ; Christensen, Karl B ; Nersting, Jacob ; Faber, Marianne ; Schmiegelow, Kjeld ; Larsen, Hanne B. / Testing physical function in children undergoing intense cancer treatment-a RESPECT feasibility study. In: Pediatric Blood & Cancer. 2018 ; Vol. 65, No. 8.

Bibtex

@article{198844c0cd114493ad700cae757fa7d8,
title = "Testing physical function in children undergoing intense cancer treatment-a RESPECT feasibility study",
abstract = "BACKGROUND: The physical function of children with cancer is reduced during treatment, which can compromise the quality of life and increase the risk of chronic medical conditions. The study, {"}REhabilitation, including Social and Physical activity and Education in Children and Teenagers with cancer{"} (Clinicaltrials.gov: NCT01772862) examines the efficacy of multimodal rehabilitation strategies introduced at cancer diagnosis. This article addresses the feasibility of and obstacles to testing physical function in children with cancer.METHODS: The intervention group comprised 46 males and 29 females aged 6-18 years (mean ± SD: 11.3 ± 3.1 years) diagnosed with cancer from January 2013 to April 2016. Testing at diagnosis and after 3 months included timed-up-and-go, sit-to-stand, flamingo balance, handgrip strength, and the bicycle ergometer cardiopulmonary exercise test (CPET).RESULTS: Of the 75 children, 92% completed a minimum of one test; two children declined testing and four were later included. Completion was low for CPET (38/150, 25%) but was high for handgrip strength (122/150, 81%). Tumor location, treatment-related side effects, and proximity to chemotherapy administration were primary obstacles for testing physical function. Children with extracranial solid tumors and central nervous system tumors completed significantly fewer tests than those with leukemia and lymphoma. Children with leukemia demonstrated reduced lower extremity function, that is, 24% reduction at 3 months testing in timed-up-and-go (P = 0.005) and sit-to-stand (P = 0.002), in contrast with no reductions observed in the other diagnostic groups.CONCLUSION: Children with cancer are generally motivated to participate in physical function tests. Future studies should address diagnosis specific obstacles and design testing modalities that facilitate physical function tests in this target group.",
author = "Nielsen, {Martin K. F.} and Christensen, {Jesper F.} and Frandsen, {Thomas L} and Troels Thorsteinsson and Andersen, {Lars B.} and Christensen, {Karl B} and Jacob Nersting and Marianne Faber and Kjeld Schmiegelow and Larsen, {Hanne B.}",
note = "{\textcopyright} 2018 Wiley Periodicals, Inc.",
year = "2018",
doi = "10.1002/pbc.27100",
language = "English",
volume = "65",
journal = "Pediatric Blood & Cancer",
issn = "1545-5009",
publisher = "JohnWiley & Sons, Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Testing physical function in children undergoing intense cancer treatment-a RESPECT feasibility study

AU - Nielsen, Martin K. F.

AU - Christensen, Jesper F.

AU - Frandsen, Thomas L

AU - Thorsteinsson, Troels

AU - Andersen, Lars B.

AU - Christensen, Karl B

AU - Nersting, Jacob

AU - Faber, Marianne

AU - Schmiegelow, Kjeld

AU - Larsen, Hanne B.

N1 - © 2018 Wiley Periodicals, Inc.

PY - 2018

Y1 - 2018

N2 - BACKGROUND: The physical function of children with cancer is reduced during treatment, which can compromise the quality of life and increase the risk of chronic medical conditions. The study, "REhabilitation, including Social and Physical activity and Education in Children and Teenagers with cancer" (Clinicaltrials.gov: NCT01772862) examines the efficacy of multimodal rehabilitation strategies introduced at cancer diagnosis. This article addresses the feasibility of and obstacles to testing physical function in children with cancer.METHODS: The intervention group comprised 46 males and 29 females aged 6-18 years (mean ± SD: 11.3 ± 3.1 years) diagnosed with cancer from January 2013 to April 2016. Testing at diagnosis and after 3 months included timed-up-and-go, sit-to-stand, flamingo balance, handgrip strength, and the bicycle ergometer cardiopulmonary exercise test (CPET).RESULTS: Of the 75 children, 92% completed a minimum of one test; two children declined testing and four were later included. Completion was low for CPET (38/150, 25%) but was high for handgrip strength (122/150, 81%). Tumor location, treatment-related side effects, and proximity to chemotherapy administration were primary obstacles for testing physical function. Children with extracranial solid tumors and central nervous system tumors completed significantly fewer tests than those with leukemia and lymphoma. Children with leukemia demonstrated reduced lower extremity function, that is, 24% reduction at 3 months testing in timed-up-and-go (P = 0.005) and sit-to-stand (P = 0.002), in contrast with no reductions observed in the other diagnostic groups.CONCLUSION: Children with cancer are generally motivated to participate in physical function tests. Future studies should address diagnosis specific obstacles and design testing modalities that facilitate physical function tests in this target group.

AB - BACKGROUND: The physical function of children with cancer is reduced during treatment, which can compromise the quality of life and increase the risk of chronic medical conditions. The study, "REhabilitation, including Social and Physical activity and Education in Children and Teenagers with cancer" (Clinicaltrials.gov: NCT01772862) examines the efficacy of multimodal rehabilitation strategies introduced at cancer diagnosis. This article addresses the feasibility of and obstacles to testing physical function in children with cancer.METHODS: The intervention group comprised 46 males and 29 females aged 6-18 years (mean ± SD: 11.3 ± 3.1 years) diagnosed with cancer from January 2013 to April 2016. Testing at diagnosis and after 3 months included timed-up-and-go, sit-to-stand, flamingo balance, handgrip strength, and the bicycle ergometer cardiopulmonary exercise test (CPET).RESULTS: Of the 75 children, 92% completed a minimum of one test; two children declined testing and four were later included. Completion was low for CPET (38/150, 25%) but was high for handgrip strength (122/150, 81%). Tumor location, treatment-related side effects, and proximity to chemotherapy administration were primary obstacles for testing physical function. Children with extracranial solid tumors and central nervous system tumors completed significantly fewer tests than those with leukemia and lymphoma. Children with leukemia demonstrated reduced lower extremity function, that is, 24% reduction at 3 months testing in timed-up-and-go (P = 0.005) and sit-to-stand (P = 0.002), in contrast with no reductions observed in the other diagnostic groups.CONCLUSION: Children with cancer are generally motivated to participate in physical function tests. Future studies should address diagnosis specific obstacles and design testing modalities that facilitate physical function tests in this target group.

U2 - 10.1002/pbc.27100

DO - 10.1002/pbc.27100

M3 - Journal article

C2 - 29741279

VL - 65

JO - Pediatric Blood & Cancer

JF - Pediatric Blood & Cancer

SN - 1545-5009

IS - 8

M1 - e27100

ER -

ID: 199062483