Polygenic liability, stressful life events and risk for secondary-treated depression in early life: a nationwide register-based case-cohort study

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Polygenic liability, stressful life events and risk for secondary-treated depression in early life : a nationwide register-based case-cohort study. / Musliner, Katherine L; Andersen, Klaus K.; Agerbo, Esben; Albiñana, Clara; Vilhjalmsson, Bjarni J; Rajagopal, Veera M; Bybjerg-Grauholm, Jonas; Bækved-Hansen, Marie; Pedersen, Carsten B.; Pedersen, Marianne G.; Munk-Olsen, Trine; Benros, Michael E; Als, Thomas D; Grove, Jakob; Werge, Thomas; Børglum, Anders D; Hougaard, David M; Mors, Ole; Nordentoft, Merete; Mortensen, Preben B; Suppli, Nis P; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.

In: Psychological Medicine, Vol. 53, 2023, p. 217–226.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Musliner, KL, Andersen, KK, Agerbo, E, Albiñana, C, Vilhjalmsson, BJ, Rajagopal, VM, Bybjerg-Grauholm, J, Bækved-Hansen, M, Pedersen, CB, Pedersen, MG, Munk-Olsen, T, Benros, ME, Als, TD, Grove, J, Werge, T, Børglum, AD, Hougaard, DM, Mors, O, Nordentoft, M, Mortensen, PB, Suppli, NP & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2023, 'Polygenic liability, stressful life events and risk for secondary-treated depression in early life: a nationwide register-based case-cohort study', Psychological Medicine, vol. 53, pp. 217–226. https://doi.org/10.1017/S0033291721001410

APA

Musliner, K. L., Andersen, K. K., Agerbo, E., Albiñana, C., Vilhjalmsson, B. J., Rajagopal, V. M., Bybjerg-Grauholm, J., Bækved-Hansen, M., Pedersen, C. B., Pedersen, M. G., Munk-Olsen, T., Benros, M. E., Als, T. D., Grove, J., Werge, T., Børglum, A. D., Hougaard, D. M., Mors, O., Nordentoft, M., ... Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2023). Polygenic liability, stressful life events and risk for secondary-treated depression in early life: a nationwide register-based case-cohort study. Psychological Medicine, 53, 217–226. https://doi.org/10.1017/S0033291721001410

Vancouver

Musliner KL, Andersen KK, Agerbo E, Albiñana C, Vilhjalmsson BJ, Rajagopal VM et al. Polygenic liability, stressful life events and risk for secondary-treated depression in early life: a nationwide register-based case-cohort study. Psychological Medicine. 2023;53:217–226. https://doi.org/10.1017/S0033291721001410

Author

Musliner, Katherine L ; Andersen, Klaus K. ; Agerbo, Esben ; Albiñana, Clara ; Vilhjalmsson, Bjarni J ; Rajagopal, Veera M ; Bybjerg-Grauholm, Jonas ; Bækved-Hansen, Marie ; Pedersen, Carsten B. ; Pedersen, Marianne G. ; Munk-Olsen, Trine ; Benros, Michael E ; Als, Thomas D ; Grove, Jakob ; Werge, Thomas ; Børglum, Anders D ; Hougaard, David M ; Mors, Ole ; Nordentoft, Merete ; Mortensen, Preben B ; Suppli, Nis P ; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. / Polygenic liability, stressful life events and risk for secondary-treated depression in early life : a nationwide register-based case-cohort study. In: Psychological Medicine. 2023 ; Vol. 53. pp. 217–226.

Bibtex

@article{cf3258aeb28045a3b958202e413a65d7,
title = "Polygenic liability, stressful life events and risk for secondary-treated depression in early life: a nationwide register-based case-cohort study",
abstract = "BACKGROUND: In this study, we examined the relationship between polygenic liability for depression and number of stressful life events (SLEs) as risk factors for early-onset depression treated in inpatient, outpatient or emergency room settings at psychiatric hospitals in Denmark.METHODS: Data were drawn from the iPSYCH2012 case-cohort sample, a population-based sample of individuals born in Denmark between 1981 and 2005. The sample included 18 532 individuals who were diagnosed with depression by a psychiatrist by age 31 years, and a comparison group of 20 184 individuals. Information on SLEs was obtained from nationwide registers and operationalized as a time-varying count variable. Hazard ratios and cumulative incidence rates were estimated using Cox regressions.RESULTS: Risk for depression increased by 35% with each standard deviation increase in polygenic liability (p < 0.0001), and 36% (p < 0.0001) with each additional SLE. There was a small interaction between polygenic liability and SLEs (β = -0.04, p = 0.0009). The probability of being diagnosed with depression in a hospital-based setting between ages 15 and 31 years ranged from 1.5% among males in the lowest quartile of polygenic liability with 0 events by age 15, to 18.8% among females in the highest quartile of polygenic liability with 4+ events by age 15.CONCLUSIONS: These findings suggest that although there is minimal interaction between polygenic liability and SLEs as risk factors for hospital-treated depression, combining information on these two important risk factors could potentially be useful for identifying high-risk individuals.",
author = "Musliner, {Katherine L} and Andersen, {Klaus K.} and Esben Agerbo and Clara Albi{\~n}ana and Vilhjalmsson, {Bjarni J} and Rajagopal, {Veera M} and Jonas Bybjerg-Grauholm and Marie B{\ae}kved-Hansen and Pedersen, {Carsten B.} and Pedersen, {Marianne G.} and Trine Munk-Olsen and Benros, {Michael E} and Als, {Thomas D} and Jakob Grove and Thomas Werge and B{\o}rglum, {Anders D} and Hougaard, {David M} and Ole Mors and Merete Nordentoft and Mortensen, {Preben B} and Suppli, {Nis P} and {Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium}",
year = "2023",
doi = "10.1017/S0033291721001410",
language = "English",
volume = "53",
pages = "217–226",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "Cambridge University Press",

}

RIS

TY - JOUR

T1 - Polygenic liability, stressful life events and risk for secondary-treated depression in early life

T2 - a nationwide register-based case-cohort study

AU - Musliner, Katherine L

AU - Andersen, Klaus K.

AU - Agerbo, Esben

AU - Albiñana, Clara

AU - Vilhjalmsson, Bjarni J

AU - Rajagopal, Veera M

AU - Bybjerg-Grauholm, Jonas

AU - Bækved-Hansen, Marie

AU - Pedersen, Carsten B.

AU - Pedersen, Marianne G.

AU - Munk-Olsen, Trine

AU - Benros, Michael E

AU - Als, Thomas D

AU - Grove, Jakob

AU - Werge, Thomas

AU - Børglum, Anders D

AU - Hougaard, David M

AU - Mors, Ole

AU - Nordentoft, Merete

AU - Mortensen, Preben B

AU - Suppli, Nis P

AU - Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

PY - 2023

Y1 - 2023

N2 - BACKGROUND: In this study, we examined the relationship between polygenic liability for depression and number of stressful life events (SLEs) as risk factors for early-onset depression treated in inpatient, outpatient or emergency room settings at psychiatric hospitals in Denmark.METHODS: Data were drawn from the iPSYCH2012 case-cohort sample, a population-based sample of individuals born in Denmark between 1981 and 2005. The sample included 18 532 individuals who were diagnosed with depression by a psychiatrist by age 31 years, and a comparison group of 20 184 individuals. Information on SLEs was obtained from nationwide registers and operationalized as a time-varying count variable. Hazard ratios and cumulative incidence rates were estimated using Cox regressions.RESULTS: Risk for depression increased by 35% with each standard deviation increase in polygenic liability (p < 0.0001), and 36% (p < 0.0001) with each additional SLE. There was a small interaction between polygenic liability and SLEs (β = -0.04, p = 0.0009). The probability of being diagnosed with depression in a hospital-based setting between ages 15 and 31 years ranged from 1.5% among males in the lowest quartile of polygenic liability with 0 events by age 15, to 18.8% among females in the highest quartile of polygenic liability with 4+ events by age 15.CONCLUSIONS: These findings suggest that although there is minimal interaction between polygenic liability and SLEs as risk factors for hospital-treated depression, combining information on these two important risk factors could potentially be useful for identifying high-risk individuals.

AB - BACKGROUND: In this study, we examined the relationship between polygenic liability for depression and number of stressful life events (SLEs) as risk factors for early-onset depression treated in inpatient, outpatient or emergency room settings at psychiatric hospitals in Denmark.METHODS: Data were drawn from the iPSYCH2012 case-cohort sample, a population-based sample of individuals born in Denmark between 1981 and 2005. The sample included 18 532 individuals who were diagnosed with depression by a psychiatrist by age 31 years, and a comparison group of 20 184 individuals. Information on SLEs was obtained from nationwide registers and operationalized as a time-varying count variable. Hazard ratios and cumulative incidence rates were estimated using Cox regressions.RESULTS: Risk for depression increased by 35% with each standard deviation increase in polygenic liability (p < 0.0001), and 36% (p < 0.0001) with each additional SLE. There was a small interaction between polygenic liability and SLEs (β = -0.04, p = 0.0009). The probability of being diagnosed with depression in a hospital-based setting between ages 15 and 31 years ranged from 1.5% among males in the lowest quartile of polygenic liability with 0 events by age 15, to 18.8% among females in the highest quartile of polygenic liability with 4+ events by age 15.CONCLUSIONS: These findings suggest that although there is minimal interaction between polygenic liability and SLEs as risk factors for hospital-treated depression, combining information on these two important risk factors could potentially be useful for identifying high-risk individuals.

U2 - 10.1017/S0033291721001410

DO - 10.1017/S0033291721001410

M3 - Journal article

C2 - 33949298

VL - 53

SP - 217

EP - 226

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

ER -

ID: 270573491